If we speak about hotel website for a small and medium business, it will be nice if it has such features as beautiful, usable design, light coding, user-friendly navigation, quality photos, good 'click to action' buttons, readable information, and some frames from booking portals OR Own Booking Module.
If you use iframes from booking.com, for example, it is much quicker to implement and easier to handle, you also have traffic from this portal, but you pay per/customer fee and have a limit of how your click to action forms and buttons look like. So, in conclusion, I would recommend you to use your Own Booking System only if you know your customers will cost you less in this case or you need a custom more luxury design for your website.
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